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SBI-477
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
SBI-477图片
CAS NO:781628-99-7
包装与价格:
包装价格(元)
1 mg电议
5 mg电议
10 mg电议
25 mg电议
50 mg电议
100 mg电议
200 mg电议
500 mg电议
1 mL*10 mM(in DMSO)电议

产品介绍
SBI-477 是化学探针,能够使转录因子MondoA失活,刺激胰岛素信号传导,使胰岛素途径抑制剂硫氧还蛋白相互作用蛋白和抑制蛋白结构域 4 的表达降低。它能够协调地抑制三酰基甘油酯合成,促进人骨骼肌细胞中的基础葡萄糖摄取。

产品描述

SBI-477 is a chemical probe stimulated insulin signaling by deactivating the transcription factor MondoA. SBI-477 coordinately inhibits triacylglyceride (TAG) synthesis and enhances basal glucose uptake in human skeletal myocytes.

体内活性

SBI-477, that coordinately inhibited triacylglyceride (TAG) synthesis and enhanced basal glucose uptake in human skeletal myocytes.??SBI-477 stimulated insulin signaling by deactivating the transcription factor MondoA, leading to reduced expression of the insulin pathway suppressors thioredoxin-interacting protein (TXNIP) and arrestin domain-containing 4 (ARRDC4).?Depleting MondoA in myocytes reproduced the effects of SBI-477 on glucose uptake and myocyte lipid accumulation.

Cas No.

781628-99-7

分子式

C24H25N3O6S

分子量

483.54

别名

SBI-477

储存和溶解度

DMSO:65 mg/mL (134.43 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years