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Pomalidomide-amido-PEG3-C2-NH2
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Pomalidomide-amido-PEG3-C2-NH2图片
CAS NO:2328070-52-4
包装与价格:
包装价格(元)
100 mg电议
500 mg电议

产品名称
E3 ligase Ligand-Linker Conjugates 55
Cereblon Ligand-Linker Conjugates 22
产品介绍

产品描述

Pomalidomide-amido-PEG3-C2-NH2 (Cereblon Ligand-Linker Conjugates 22) is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and 3-unit PEG linker used in PROTAC technology[1].

体外活性

Pomalidomide-amido-PEG3-C2-NH2 (Compound 5b) can be used to synthesize BI-3663. BI-3663 (cereblon-based) degrades focal adhesion tyrosine kinase (PTK2) with a median DC50 of 30 nM to >80% across a panel of 11 human hepatocellular carcinoma (HCC) cell lines[1].

Cas No.

2328070-52-4

分子式

C22H28N4O8

分子量

476.48

别名

E3 ligase Ligand-Linker Conjugates 55;Cereblon Ligand-Linker Conjugates 22;Pomalidomide-amido-PEG3-C2-NH2

储存和溶解度

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years