产品描述
BMS-654457 is a small-molecule, reversible inhibitor of factor XIa (FXIa; Kis: 0.2 and 0.42 nM for human and rabbit FXIa).
体外活性
BMS-654457 shows comparable in vitro potency against FXIa and was over 500-fold selective against coagulation-related proteases (thrombin, FXa, and FVIIa) in these species.
体内活性
BMS-654457 is potent in the prevention of arterial thrombosis in rabbits with limited effects on bleeding time.
Cas No.
1004551-41-0
分子式
C36H37N5O4
分子量
603.71
别名
BMS-654457
储存和溶解度
(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years