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PF-00446687
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
PF-00446687图片
CAS NO:862281-92-3
包装与价格:
包装价格(元)
50 mg电议
100 mg电议

产品介绍

产品描述

PF-00446687 is a selective agonist of melanocortin-4 receptor (MC4R) (EC50 of 12 ± 1 nM).

体外活性

PF-00446687 has a relatively weak activity at the MC1, MC3, and MC5 receptors(EC50s of 1.02±0.30 μM, 1.16±0.35 μM, and 1.98±0.20 μM, respectively).

体内活性

Peripheral administration of the brain penetrant MC3/4R receptor peptide agonist, Melanotan II (MTII), and the highly selective, small molecule MC4R agonist, Pf-446687, enhances partner preference formation in the prairie vole, but not in the non-monogamous meadow vole[2].

Cas No.

862281-92-3

分子式

C28H36F2N2O2

分子量

470.59

别名

PF-00446687

储存和溶解度

DMSO:62.5 mg/mL (132.81 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years