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LTX-401 dihydrochloride(1262851-70-6 free base)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
LTX-401 dihydrochloride(1262851-70-6 free base)图片
包装与价格:
包装价格(元)
100 mg电议
500 mg电议

产品名称
LTX-401 dihydrochloride
LTX-401 dihydrochloride (1262851-70-6 free base)
产品介绍

产品描述

LTX-401, targets the Golgi apparatus, and is an oncolytic amino acid derivative.

体外活性

LTX-401 displays the highest cytotoxic activity against the human malignant melanoma cell line MDA-MB-435S (13.5 μM), and is least active against the human hepatocellular carcinoma cell line HEPG2 (35.4 μM). For the remaining cell lines, LTX-401 exhibits similar IC50 values, varying slightly within the range of 19-32 μM. No in vitro hemolytic activity against RBCs is observed using the same concentrations required for the induction of cell death in cancer cell lines. A 50% hemolysis is observed using higher concentrations of LTX-401 (400 μg/mL=1087 μM)[1].LTX-401, an oncolytic amino acid derivative, targets the Golgi apparatus[2].?LTX-401 effectively reduces the viability of several tumor cell lines in vitro, with a similar degree of cytotoxicity against non-malignant cell lines such as HUV-EC-C endothelial cells, HaCat keratinocytes and MRC-5 fibroblasts.

体内活性

The majority ?of the animals demonstrate a complete and lasting tumor regression after intratumoral treatment with LTX-401.?Samples are collected from selected animals in the treatment group and control group on days 2 and 7 post-treatment with a single i.t injection.?The immunolabelling of tumor tissue with anti-CD3 antibody reveals that a majority of the infiltrating cells are CD3+ T cells, whereas tumors injected with vehicle only exhibit tumors with a viable tumor tissue, with minimal necrosis and few lymphocytes[1].

Cas No.

T13759

分子式

C23H35Cl2N3O

分子量

440.45

别名

LTX-401 dihydrochloride;LTX-401 dihydrochloride (1262851-70-6 free base)

储存和溶解度

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years