TRK-IN-12 (Compound 9e) 是一种有效的TRK抑制剂 (TRKG595RIC50= 13.1 nM)。TRK-IN-12 是一种大环衍生化合物。TRK-IN-12 在 Ba/F3-LMNA-NTRK1 细胞系中显示出显着的抗增殖活性 (IC50= 0.080 μM)。TRK-IN-12 在 Ba/F3-LMNA-NTRK1-G595R 细胞系中显示出比对照药物 LOXO-101 更好的抑制作用 (IC50= 0.646 μM)。

TRK-IN-12 (Compound 9e) is a potent inhibitor of TRK (TRK G595R IC 50 = 13.1 nM). TRK-IN-12 is a macrocyclic derivative compound. TRK-IN-12 shows significant antiproliferative activity in the Ba/F3-LMNA-NTRK1 cell line ( IC 50 = 0.080 μM). TRK-IN-12 has shown a better inhibitory effect ( IC 50 = 0.646 μM) than control drug LOXO-101 in Ba/F3-LMNA-NTRK1-G595R cell line [1].

C18H19ClFN5O3S

439.89

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years