LCS3 是谷胱甘肽二硫化物还原酶 (GSR) 和硫氧还蛋白还原酶1 (TXNRD1)的可逆和非竞争性协同抑制剂， IC50分别为 3.3 μM 和 3.8 μM。LCS3 具有抗肿瘤活性并能诱导细胞凋亡。LCS3 可用于研究肺腺癌 (LUAD) 。

LCS3 (5 nM-10 μM; 96 h) inhibits lung cancer cell lines while not inhibiting non-transformed lung cells [1]. LCS3 (3 μM; 96 h) selectively kills lung adenocarcinoma (LUAD) cell lines, in part by inducing apoptosis [1]. LCS3 induces the activation of ROS and NRF2 pathways in sensitive lung adenocarcinoma (LUAD) cells [1]. Cell Viability Assay [1] Cell Line: Non-small cell lung cancer (NSCLC) cells and non-transformed lung cells Concentration: 5 nM-10 μM Incubation Time: 96 hours Result: Inhibited the 24/25 NSCLC cell lines grow at low micromolar concentrations (IC 50<5 μM) and the non-transformed lung cell lines were relatively insensitive (IC 50 >10 μM). Apoptosis Analysis [1] Cell Line: lung adenocarcinoma (LUAD) cells Concentration: 3 μM Incubation Time: 96 hours Result: The cleavage of caspase 3, caspase 7, and/or PARP1 was increased in all LCS3-sensitive LUAD cell lines. Cell Viability Assay [1] Cell Line: H23 and H1650 cells Concentration: 3 μM Incubation Time: 3, 6, and 12 hours Result: In response to LCS3 by accumulating ROS and activating the NRF2 transcription program.

LCS3 is a reversible and non-competitive synergistic inhibitor of glutathione disulfide reductase (GSR) and thioredoxin reductase 1 (TXNRD1) with IC50s of 3.3 μM and 3.8 μM, respectively. LCS3 exhibits anti-tumor activity and induces apoptosis. LCS3 can be used to study lung adenocarcinoma (LUAD)[1].

LCS3 (5 nM-10 μM; 96 h) inhibits lung cancer cell lines while not inhibiting non-transformed lung cells [1]. LCS3 (3 μM; 96 h) selectively kills lung adenocarcinoma (LUAD) cell lines, in part by inducing apoptosis [1]. LCS3 induces the activation of ROS and NRF2 pathways in sensitive lung adenocarcinoma (LUAD) cells [1]. Cell Viability Assay [1] Cell Line: Non-small cell lung cancer (NSCLC) cells and non-transformed lung cells Concentration: 5 nM-10 μM Incubation Time: 96 hours Result: Inhibited the 24/25 NSCLC cell lines grow at low micromolar concentrations (IC 50<5 μm) and the non-transformed lung cell lines were relatively insensitive (ic 50>10 μM). Apoptosis Analysis [1] Cell Line: lung adenocarcinoma (LUAD) cells Concentration: 3 μM Incubation Time: 96 hours Result: The cleavage of caspase 3, caspase 7, and/or PARP1 was increased in all LCS3-sensitive LUAD cell lines. Cell Viability Assay [1] Cell Line: H23 and H1650 cells Concentration: 3 μM Incubation Time: 3, 6, and 12 hours Result: In response to LCS3 by accumulating ROS and activating the NRF2 transcription program.

109844-92-0

C11H7ClN2O4

266.64

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years