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TG 100713
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
TG 100713图片
CAS NO:925705-73-3
包装与价格:
包装价格(元)
2 mg电议
5 mg电议
10 mg电议
25 mg电议
50 mg电议
100 mg电议
1 mL*10 mM(in DMSO)电议

产品名称
TG100713
产品介绍
TG100713 是一种PI3K的抑制剂,抑制PI3Kδ,γ,α和β的IC50值分别为24、50、165 和 215 nM。

产品描述

TG100713 is a pan-PI3K inhibitor against PI3Kγ, PI3Kδ, PI3Kα and PI3Kβ with IC50 of 50 nM, 24 nM, 165 nM and 215 nM, respectively.

体外活性

TG 100713 also strongly inhibits EC proliferation. [1]

激酶实验

Kinase Assays: PI3K reactions are constructed by using recombinant human kinases, 3 μM ATP, phosphatidylinositol substrate, and cofactors, and reaction progression measured by using a luminescent-based detection system to quantify ATP consumption. Protein kinase assays are performed by using commercial screening services.

细胞实验

Human umbilical vein EC plated in 96-well cluster plates (5,000 cells/well) are cultured in assay medium (containing 0.5% serum and 50 ng/ml VEGF) in the presence or absence of test compounds (10 μM), and cell numbers are quantified by XTT assay.(Only for Reference)

Cas No.

925705-73-3

分子式

C12H10N6O

分子量

254.253

别名

TG100713;TG 100713

储存和溶解度

DMSO:2.5 mg/mL (10 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years