产品描述
CDK4/6-IN-3 is a brain-penetrant CDK4/CDK6 inhibitor (Kis:<0.3 nM and 2.2 nM) used for the treatment of glioblastoma. It inhibits CDK1 with a Ki of 110 nM.
体外活性
CDK4/6-IN-3 inhibits MCF7 and BT549 cell lines proliferation (EC50s: 30 nM and 2.1 μM).
Cas No.
2366237-37-6
分子式
C25H31FN8
分子量
462.57
别名
CDK4/6-IN-3
储存和溶解度
(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years