(R)-CR8 trihydrochloride is a potent inhibitor CDK1/2/5/7/9.

(R)-CR8 trihydrochloride is a potent apoptotic cell death inducer(SH-SY5Y cell line with an IC50 of 0.49 μM ). (R)-CR8 trihydrochloride (0.25-10 μM) induces a dose-dependent induction of poly-(ADP-ribose)polymerase (PARP) cleavage[1].

CR8 treatment attenuated sensorimotor and cognitive deficits, alleviated depressive-like symptoms, and decreased lesion volume.

1786438-30-9

C24H32Cl3N7O

540.92

CR8, (R)-Isomer trihydrochloride;(R)-CR8 trihydrochloride;(R)-CR8 trihydrochloride

DMSO:62.5 mg/mL (115.54 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years