SK1-IN-1 is a potent inhibitor of sphingosine kinase 1 (SPHK1)(IC50 of 58 nM).

SK1-IN-1 shows significant improvement in the intrinsic clearance, particularly against human liver microsomes. SK1-IN-1 is selected for rat PK studies and demonstrates modest in oral bioavailability with acceptable half-lives in blood circulation.

1218816-71-7

C22H30N4O3

398.5

SK1-IN-1

DMSO:100 mg/mL (250.94 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years