产品描述
INT-767 is a dual farnesoid X receptor (FXR)/TGR5 agonist with mean EC50s of 30 and 630 nM, respectively.
体外活性
INT-767 does not show cytotoxic effects in HepG2 cells, does not inhibit cytochrome P450 enzymes, does not inhibit the human ether-a-go-go-related gene potassium channel.is highly stable to phase I and II enzymatic modifications.
体内活性
INT-767 decreases triglyceride levels and plasma total cholesterol in db/m and db/db mice.
Cas No.
1000403-03-1
分子式
C25H44NaO6S
分子量
495.67
别名
INT-767
储存和溶解度
DMSO:205.5 mg/mL (415.44 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years