CP 316311 is a selective CRF1 receptor antagonist (IC50: 6.8 nM).

CP 316311 fully antagonizes CRF-stimulated adenylate cyclase activity in the rat cortex and at human CRF1 receptors endogenously expressed in IMR32 cells (apparent Kis: 7.6 and 8.5 nM).

CP 316311 blocks the effects of both the exogenous and endogenous CRF in the CNS and it also blocks the effects induced by the exogenous or endogenous CRF in the brain in rat models. CP 316311 (3.2 mg/kg) inhibits 125I-oCRF binding by >80% in rats. CP 316311 significantly attenuates the activation of the hypothalamic?pituitary?adrenal (HPA) axis (MED:10 mg/kg, p.o.).

175139-41-0

C21H29NO2

327.46

CP 316311

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years