O-2050 是一种高亲和力的大麻素CB1受体拮抗剂,Ki为 2.5 nM。O-2050 抑制大麻素 CB2受体,Ki为 0.2 nM。O-2050 减少了小鼠的食物摄入量,并且引起小鼠运动。
产品描述
O-2050 is a high affinity cannabinoid CB 1 receptor antagonist with a K i of 2.5 nM. O-2050 inhibits cannabinoid CB 2 receptor with Ki of 0.2 nM. O-2050 decreased food intake in mice and caused locomotor stimulation in mice [1].
体内活性
O-2050 (1, 3, 10, 30 mg/kg; ip; pretreatment 30 mins) produces significant and dose-dependent decreases in food intake in mice. O-2050 (10, 30 mg/kg) markedly causes locomotor stimulation [1].
Cas No.
1883545-42-3
分子式
C23H31NO4S
分子量
417.56
别名
O-2050
储存和溶解度
DMSO:<41.76mg/ml
Ethanol:<41.76mg/mL
Powder: -20°C for 3 years
In solvent: -80°C for 2 years