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Leukotriene B4 Ethanolamide
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Leukotriene B4 Ethanolamide图片
CAS NO:877459-63-7
包装:1 mg
市场价:-1元

产品介绍

产品描述

The effects of Leukotriene B4 (LTB4) are mediated by two known receptors, BLT1 and BLT2. LTB4 is a high affinity ligand for BLT1, and many of its pro-inflammatory effects are believed to be transduced through this receptor. The BLT2 is more enigmatic, in that LTB4 is not a high-affinity ligand, nor is it clear that BLT2 activation promotes inflammation. LTB4 ethanolamide (LTB4-EA) is a theoretical 5-LO metabolite of arachidonoyl ethanolamide (AEA). In CHO cells transfected with human BLTR1, LTB4-EA was a potent antagonist with about three times greater affinity for the receptor than LTB4 (Ki = 1.22 nM versus 3.88 nM). LTB4-EA antagonizes the LTB4-induced contractions of guinea pig lung parenchyma with an EC50 of 10 nM. LTB4-EA thus represents a potential endogenous anti-inflammatory compound functioning as a natural antagonist of BLTR1.

Cas No.

877459-63-7

分子式

C22H37NO4

分子量

379.541

别名

Leukotriene B4 Ethanolamide

储存和溶解度

DMF:100 mg/mL
PBS (pH 7.2):12 mg/mL
Ethanol:100 mg/mL
DMSO:100 mg/mL
Powder: -20°C for 3 years
In solvent: -80°C for 2 years