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14,15-dehydro Leukotriene B4
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
14,15-dehydro Leukotriene B4图片
CAS NO:114616-11-4
包装:1 mg
市场价:18540元

产品介绍

产品描述

Leukotriene B4 (LTB4) is a dihydroxy fatty acid derived from arachidonic acid through the 5-lipoxygenase pathway. It promotes a number of leukocyte functions including aggregation, stimulation of ion fluxes, enhancement of lysosomal enzyme release, superoxide anion production, chemotaxis, and chemokinesis. At least two LTB4 receptors, termed BLT1 and BLT2, have been identified. 14,15-dehydro LTB4 is a LTB4 receptor antagonist that has a higher binding affinity for BLT1, demonstrating a Ki value of 27 nM, compared to BLT2, which has a Ki value of 473 nM. 14,15-dehydro LTB4 inhibits LTB4-induced release of lysozymes from rat polymorphonuclear leukoctyes with an IC50 value of 1 μM.

Cas No.

114616-11-4

分子式

C20H30O4

分子量

334.45

别名

14,15-dehydro Leukotriene B4;14,15-dehydro Leukotriene B4

储存和溶解度

Ethanol:Miscible
DMSO:Miscible
PBS (pH 7.2):>1 mg/mL
DMF:Miscible
Powder: -20°C for 3 years
In solvent: -80°C for 2 years