产品描述
Leukotriene B4 (LTB4) is a dihydroxy fatty acid derived from arachidonic acid through the 5-lipoxygenase pathway. It promotes a number of leukocyte functions including aggregation, stimulation of ion fluxes, enhancement of lysosomal enzyme release, superoxide anion production, chemotaxis, and chemokinesis. At least two LTB4 receptors, termed BLT1 and BLT2, have been identified. 14,15-dehydro LTB4 is a LTB4 receptor antagonist that has a higher binding affinity for BLT1, demonstrating a Ki value of 27 nM, compared to BLT2, which has a Ki value of 473 nM. 14,15-dehydro LTB4 inhibits LTB4-induced release of lysozymes from rat polymorphonuclear leukoctyes with an IC50 value of 1 μM.
Cas No.
114616-11-4
分子式
C20H30O4
分子量
334.45
别名
14,15-dehydro Leukotriene B4;14,15-dehydro Leukotriene B4
储存和溶解度
Ethanol:Miscible
DMSO:Miscible
PBS (pH 7.2):>1 mg/mL
DMF:Miscible
Powder: -20°C for 3 years
In solvent: -80°C for 2 years