TCS PrP Inhibitor 13 是一种抗朊病毒剂，可抑制蛋白酶抗性朊病毒蛋白的积累。它诱导神经鞘瘤细胞调亡，在ScN2a和F3细胞株中均显示IC50值为3 nM。

TCS PrP Inhibitor 13 is an antiprion agent inhibiting protease-resistant prion protein (PrP-res) accumulation.

In Schwannoma cells, administration of 0-500 μM TCS PrP Inhibitor 13 reduces levels of total ERK1/2, pAKT, total FAK, Cyclin D1, PrPC and increases expression of cleaved caspase-3 significantly. TCS PrP Inhibitor 13 also significantly reduces the number of proliferating, Ki67-positive cells and total cell number in Schwannoma cells[2].

34320-83-7

C15H11N3O3

281.27

5-(4-Nitrophenyl)-2-Phenyl-4H-Pyrazol-3-One;TCS PrP Inhibitor 13

DMSO:88 mg/mL (312.87 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years