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JAMI1001A
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
JAMI1001A图片
CAS NO:1001019-46-0
包装与价格:
包装价格(元)
5 mg电议
100 mg电议
500 mg电议

产品介绍

产品描述

JAMI1001A is a positive allosteric modulator of AMPA receptor . JAMI1001A efficaciously modulates AMPA receptor deactivation and desensitization of both flip and flop receptor isoforms.

体外活性

JAMI1001A binds in the solvent accessible allosteric pocket that lies at the interface between AMPA receptor ligand-binding core dimers. JAMI1001A efficaciously blocks channel desensitization and slows deactivation of the flip and flop isoforms of AMPA receptor GluA2[1]. A simple kinetic model suggests that JAMI1001A independently modulates both the protein rearrangements necessary for channel desensitization and its recovery from the desensitized state, and the protein rearrangements necessary for channel deactivation (closed-cleft stability or channel gating)[1].

Cas No.

1001019-46-0

分子式

C16H17F3N4O3S

分子量

402.39

别名

JAMI1001A

储存和溶解度

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years