| CAS NO: | 96156-26-2 |
Displurigen is a cell-permeable, phenylthiochromen-4-one derived compound that disrupts the pluripotency of human embryonic stem cells by targeting HSPA8/HSC70 and affects its binding to Oct4. Inhibits ATPase activity of HSP70 (IC50 = 225 μM). Displurigen has shown to diminish the mRNA levels of Oct4 and Nanog within 24 hours of treatment and causes a complete annihilation of OCT4+ and NANOG+ bearing cells within 4 days of treatment (~ 10 μM). It does not induce apoptosis and has no significant effect on cell cycle progression.
| 分子量 | 286.3 |
| 分子式 | C15H10O4S |
| CAS号 | 96156-26-2 |
| 纯度 | >98% |
| 溶解性（25°C） | DMSO: 20 mg/mL clear |
| 储存和运输条件 | 固体粉末： -20°C 冷藏长期储存 常温运输及临时存放 |
| 小鼠 | 大鼠 | 兔 | 豚鼠 | 仓鼠 | 狗 | |
| 重量 (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| 体表面积 (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km系数 | 3 | 6 | 12 | 8 | 5 | 20 |
| 动物 A (mg/kg) = 动物 B (mg/kg) × | 动物 B的Km系数 |
| 动物 A的Km系数 |
例如，依据体表面积折算法，将化合物用于小鼠的剂量20 mg/kg 换算成大鼠的剂量，需要将20 mg/kg 乘以小鼠的Km系数（3），再除以大鼠的Km系数（6），得到化合物用于大鼠的等效剂量为10 mg/kg。
以下数据基于产品分子量，对于特殊产品，请参照COA中的储备液配制条件和说明进行操作。
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.4928 mL | 17.4642 mL | 34.9284 mL |
| 5 mM | 0.6986 mL | 3.4928 mL | 6.9857 mL |
| 10 mM | 0.3493 mL | 1.7464 mL | 3.4928 mL |
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