VRK-IN-1 is a potent and selective inhibitor of vaccinia-related kinases 1 (VRK1), with an IC50 of 150 nM. VRK1 is human Ser/Thr protein kinases associated with increased cell division and neurological disorders[1].

VRK-IN-1 binds to VRK1-FL by enthalpy-driven, with a Kd of 190 nM[1].VRK-IN-1 (0.4-25 μM; 24 h) slightly decreases the viability of human HeLa cells at the concentration of 3.2 μM[1].

2378855-09-3

C18H11F4NO2

349.285

VRK-IN-1

DMSO:100 mg/mL (286.30 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years