PD173212 is a selective N-type voltage-sensitive calcium channel (VSCC) blocker. It has an IC50 of 36 nM in IMR-32 assays.

PD 173212 possesses selectivity for non L-type Ca2+ channels versus neuronal Na+, K+, and L-type Ca2+ channels. PD173212 effectively blocks recombinant B-class (N-type) calcium channel currents 78±7.8% (IC50: 74 nM), by whole-cell voltage-clamp techniques [1].

In the audiogenic seizure model, PD173212 (30 mg/kg, i.v.) displays moderate efficacy in preventing tonic seizures [1].

217171-01-2

C38H53N3O3

599.85

PD173212

DMSO:100 mg/mL (166.71 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years