Ribocil 强烈抑制GFP表达, EC50值为0.3 μM，是一种高选择性化学调节剂，调节细菌核糖核黄素核开关。

Ribocil is a highly selective chemical modulator of bacterial riboflavin riboswitches. Ribocil strongly inhibits GFP expression, achieving a 50% effective concentration (EC50: 0.3 μM).

Ribocil is a highly specific bioactive synthetic mimic of FMN, which competes with the natural ligand to inhibit FMN riboswitch-mediated expression of ribB and inhibits bacterial growth. Ribocil-B shows superior microbiological activity as compared to Ribocil-A (minimum inhibitory concentration (MIC) = 1 μg/ml versus MIC ≥ 64 μg/ml), inhibition of riboflavin synthesis (IC50 = 0.13 μM versus IC50 >26 μM), and binding affinity to the E. coli FMN aptamer (Kd = 6.6 nM versus Kd ≥ 10,000 nM) [1]

1381289-58-2

C19H22N6OS

382.48

Ribocil

DMSO:24.8 mg/mL (64.84 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years