DNA Topoisomerase II inhibitor 1 (compound 8ed) 是一种有效的DNA 拓扑异构酶 II抑制剂。DNA Topoisomerase II inhibitor 1 显示出抗增殖活性。DNA Topoisomerase II inhibitor 1 诱导细胞凋亡 (Apoptosis) 和细胞周期停滞在亚 G1 期。

DNA topoisomerase II inhibitor 1 (compound 8ed) is a potent DNA topoisomerase II inhibitor. DNA topoisomerase II inhibitor 1 shows anti-proliferative activity. DNA topoisomerase II inhibitor 1 induces apoptosis and cell cycle arrest at sub G1 phase [1].

DNA topoisomerase II inhibitor 1 (compound 8ed) (0-10 μM; 48 h) shows cytotoxic activity with IC 50 s of 10.10, >10, 0.59, 4.20, >10, >10, 8.41 μM for HT-29, MDA-MB-231, MG-63, U87MG, PC3, HeLa, Vero cells, respectively [1]. DNA topoisomerase II inhibitor 1 (0.5, 2 μM; 24 h) induces apoptosis and cell cycle arrest at sub G1 phase [1]. DNA topoisomerase II inhibitor 1 (0.5, 2 μM) increases the generation of reactive oxygen species (ROS) [1].

2459950-15-1

C28H24N4O3S

496.58

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years