Mc-Val-Cit-PABC-PNP 是一种组织蛋白酶可裂解的 ADC 肽接头，可用于合成抗体偶联药物。

MC-Val-Cit-PAB-PNP, also known as Mc-Val-Cit-PABC-PNP, is a cathepsin cleavable ADC peptide linker. For example, FDA approved drug, brentuximab vedotin, adopts this linker. Protein- and peptide-drug conjugates hold a promising stance in the delivery of therapeutic agents by providing distinct advantage of improving therapeutic potential of drugs. Use of specialized linkers makes them unique in their in vivo therapeutic application by providing target tissue-specific release of drug.

159857-81-5

C35H43N7O11

737.767

Maleimidocaproyl-L-valine-L-citrulline-p-aminobenzyl alcohol p-nitrophenyl carbonate;马来酰亚胺基己酰-L-缬氨酸-L-瓜氨酸对氨基苄醇 对硝基苯基碳酸脂;MC-Val-Cit-PABC-PNP

DMSO:37 mg/mL
Powder: -20°C for 3 years
In solvent: -80°C for 2 years