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Andarine(GTx-007)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Andarine(GTx-007)图片
CAS NO:401900-40-1
规格:≥98%
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议
1g电议
5g电议
10g电议

产品介绍
理化性质和储存条件
Molecular Weight (MW)441.36
FormulaC19H18F3N3O6
CAS No.401900-40-1
Storage-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)DMSO: 88 mg/mL (199.4 mM)
Water: <1 mg/mL
Ethanol: 88 mg/mL (199.4 mM)
Solubility (In vivo)30% PEG400+0.5% Tween80+5% Propylene glycol: 30 mg/mL
SynonymsGTx-007; S-4; GTx007; S4; GTx 007; S 4
实验参考方法
In Vitro

In vitro activity: Andarine stimulates AR-mediated transcription to 93% of that observed for 1 nM DHT at a concentration of 10 nM.

In VivoAndarine exhibits potent and efficacious anabolic activity and results in dose-dependent stimulation of growth in prostate, seminal vesicles, and levator ani muscle with the ED50 of 0.43 mg/day, 0.55 mg/day, and 0.14 mg/day, respectively. Besides, Andarine shows no dose-dependent effect on castration-induced change in FSH, and partially suppresses LH production at dose rates of 0.5 mg/day or higher. In dogs administrated by intravenous doses of Andarine (0.1, 1, 3, and 10 mg/kg), the total body clearance (CL) ranged from 7.4 mL/min/kg to 3.1 mL/min/kg, volume of distribution at steady state (Vss) is 1.39 L/kg and half-life of Andarine is 229 minutes, respectively. In addition, oral bioavailability is 38%, 62% and 91% for the 10 mg/kg, 1 mg/kg and 0.1 mg/kg doses, respectively. Andarine demonstrates tissue-selective pharmacological activity and significantly decreased prostate weight to 79.4% at a concentration of 0.5 mg/day in intact rats.
Animal modelMale Sprague-Dawley rats and castrated rat model.
Formulation & DosageDissolved in minimal amounts of ethanol and then diluted to final concentrations with PEG 300; ≤1 mg/day; Administered via osmotic pump.
References

J Pharmacol Exp Ther. 2003 Mar;304(3):1334-40; Endocrinology. 2004 Dec;145(12):5420-8.