(S,R,S)-AHPC-PEG4-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and 4-unit PEG linker used in PROTAC technology.

(S,R,S)-AHPC-PEG4-NH2 hydrochloride, extracted from patent US20170008904A1, can be used in the synthesis of compound A1895 in example 3[1].

2064292-52-8

C32H50ClN5O8S

700.29

E3 ligase Ligand-Linker Conjugates 7;VHL Ligand-Linker Conjugates 4 hydrochloride;VH032-PEG4-NH2 hydrochloride;(S,R,S)-AHPC-PEG4-NH2 hydrochloride

H2O:50 mg/mL (71.40 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years