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Thiocoraline
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Thiocoraline图片
CAS NO:173046-02-1
包装:1 mg
市场价:1804元

产品介绍

产品描述

Thiocoraline is a depsipeptide and DNAbis-intercalator originally isolated fromMicromonosporawith antibacterial and anticancer activities.1,2It is active against the Gram-positive bacteriaS. aureus,B. subtilis, andM. luteus(MICs = 0.05, 0.05, and 0.03 μg/ml, respectively) but not Gram-negativeE. coli,K. pneumoniae, orP. aeruginosa(MICs = >100 μg/ml for all).1Thiocoraline inhibits RNA and DNA polymerase and thymidylate synthase (IC50s = 6, 6, and 15 μg/ml, respectively), as well as RNA and DNA synthesisin vitro(IC50s = 0.008 and 0.4 μg/ml, respectively). It is cytotoxic to P388, A549, HT-29, and MEL-28 cancer cells (IC50s = 0.002, 0.002, 0.01, and 0.002 μg/ml, respectively).

Cas No.

173046-02-1

分子式

C48H56N10O12S6

分子量

1157.41

别名

Thiocoraline

储存和溶解度

DMSO:Soluble
Ethanol:Soluble
Dichloromethane:Soluble
Methanol:Soluble
Powder: -20°C for 3 years
In solvent: -80°C for 2 years