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O-11
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
O-11图片
CAS NO:119290-12-9
包装:25 mg
市场价:7385元

产品介绍

产品描述

O-11 is an analog of the fully saturated, 14-carbon fatty acid myristic acid, in which the methylene group at position 11 is replaced with oxygen. It is highly effective and selective at killingTrypanosoma brucei, the protozoan parasite responsible for African sleeping sickness, exhibiting an LD50of less than 1 μM in a cell culture assay.1,2The toxic effects of O-11 appear to be caused by its ability to inhibit the incorporation of a single myristate into the GPI anchor of the variant surface glycoprotein (VSG), a protein critical for evading the host immune response.1O-11 exhibits essentially no anti-fungal activity when assayed usingC. neoformans, but does have a minor inhibitory effect on HIV-1 replication in T-lymphocytes.3

Cas No.

119290-12-9

分子式

C13H26O3

分子量

230.34

别名

O-11

储存和溶解度

PBS (pH 7.2):1 mg/mL
Ethanol:30 mg/mL
DMSO:20 mg/mL
DMF:30 mg/mL
Powder: -20°C for 3 years
In solvent: -80°C for 2 years