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(R)-(-)-Ibuprofen
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
(R)-(-)-Ibuprofen图片
CAS NO:51146-57-7
包装与价格:
包装价格(元)
50 mg电议
100 mg电议
200 mg电议
500 mg电议
1 mL*10 mM(in DMSO)电议

产品名称
levibuprofen
(R)-Ibuprofen
产品介绍
(R)-(-)-Ibuprofen 是 Ibuprofen 的 R 型异构体,对 COX 无作用,可以抑制 NF-Κb 的活化;(R)-(-)-Ibuprofen 具有抗炎作用,可用于缓解疼痛的研究。

产品描述

(R)-(-)-Ibuprofen is the R enantiomer of Ibuprofen and inhibits NF-κB activation. (R)-(-)-Ibuprofen has anti-inflammatory and antinociceptive effects.

体外活性

(R)-(-)-Ibuprofen is involved in pathways of lipid metabolism and is incorporated into triglycerides along with endogenous fatty acids. (R)-(-)-Ibuprofen inhibits NF-κB luciferase activity (IC50: 121.8 μM), weaker than that of S(+)-ibuprofen (IC50, 61.7 μM). (R)-(-)-Ibuprofen (1 μM) significantly decreases NF-κB activation and fully prevents NF-κB induction at 10 μM. Furthermore, (R)-(-)-Ibuprofen (10 mM) has no effect on HSF [1][2].

Cas No.

51146-57-7

分子式

C13H18O2

分子量

206.28

别名

levibuprofen;(R)-Ibuprofen;(R)-(-)-Ibuprofen

储存和溶解度

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years