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Latanoprost ethyl amide
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Latanoprost ethyl amide图片
CAS NO:607351-44-0
包装:25 mg
市场价:11502元

产品介绍

产品描述

Latanoprost ethyl amide (Lat-NEt) is a latanoprost analog in which the C-1 carboxyl group has been modified to an N-ethyl amide. Prostaglandin esters have been shown to have ocular hypotensive activity. Prostaglandin N-ethyl amides were recently introduced as alternative prostaglandin ocular hypotensive prodrugs. Although it has been claimed that prostaglandin ethyl amides are not converted to the free acids in vivo, studies in our laboratories have shown that bovine and human corneal tissue converts the N-ethyl amides of various prostaglandins to the free acids with a conversion rate of about 2.5 μg/g corneal tissue/hr. Lat-NEt would be expected to show the typical intraocular effects of Latanoprost free acid, but with the much slower hydrolysis pharmacokinetics of the prostaglandin N-amides.

Cas No.

607351-44-0

分子式

C25H39NO4

分子量

417.58

别名

Latanoprost ethyl amide

储存和溶解度

DMSO:50 mg/mL
DMF:30 mg/mL
Ethanol:30 mg/mL
PBS (pH 7.2):200 μg/mL
Powder: -20°C for 3 years
In solvent: -80°C for 2 years