FR900098 is a derivative of fosmidomycin that has antimalarial activity (IC50s = 170, 170, and 90 nM for HB3, A2, and Dd2 P. falciparum strains, respectively). FR900098 inhibits DOXP reductoisomerase, a key enzyme in the non-mevalonate pathway of isoprenoid biosynthesis, in vitro in a dose-dependent manner. FR900098 (>10 mg/kg, i.p.) eradicated P. vinckei parasites within four days in mice.

73226-73-0

C5H12NNaO5P

220.12

FR900098 (sodium salt)

PBS (pH 7.2):5 mg/mL
Powder: -20°C for 3 years
In solvent: -80°C for 2 years