Diminutol is a cell-permeable purine derivative that inhibits the NADP-dependent oxidoreductase, NQO1 (Ki = 1.72 μM), to destabilize microtubules and disrupt mitosis. At 50 μM, it directly affects tubulin polymerization in Xenopus egg extracts without interfering with the activity of Cdk1, DNA replication, or actin polymerization.

361431-33-6

C19H26N6OS

386.51

Diminutol

DMF:30 mg/mL
Ethanol:20 mg/mL
DMSO:30 mg/mL
DMSO:PBS(pH7.2) (1:1):0.5 mg/mL
Powder: -20°C for 3 years
In solvent: -80°C for 2 years