Tianeptine 是一种选择性5-HT摄取促进剂，具有抗抑郁、抗焦虑和神经保护作用，可用于缓解疼痛的研究。

Tianeptine is a selective 5-HT uptake facilitator in vitro and in vivo.

tianeptine pretreatment upon corticosterone release and body weight loss following L-5-hydroxytryptophan (5-HTP) administration in conscious rats.?Administration of 5-HTP (20 mg/kg i.v.) increased plasma corticosterone levels to a similar extent in rats pretreated either with saline or tianeptine (10 mg/kg i.p., 60 min beforehand).?Besides, prior administration of benserazide (50 mg/kg i.p., 30 min beforehand), an inhibitor of peripheral aromatic L-amino acid decarboxylase, prevented 5-HTP-induced corticosterone release in both saline- and tianeptine-pretreated rats.?However, combined administration of benserazide and 5-HTP decreased overnight body weight in saline-, but not in tianeptine-pretreated rats.?These results suggest that tianeptine preferentially activates 5-HT reuptake in central serotonergic neurones.

72797-41-2

C21H25ClN2O4S

436.95

Tianeptine sodium;S-1574;TPI-1062;噻奈普汀;噻萘普汀;JNJ-39823277;Tianeptine

DMSO:10 mg/mL (22.89 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years