CaV1.3 antagonist-1 是一种有效且高度选择性的CaV1.3L 型钙通道拮抗剂，IC50为 1.7 μM。CaV1.3 antagonist-1 对 CaV1.3 LTCC 的抑制比 CaV1.2 LTCC 强 600 倍以上。CaV1.3 antagonist-1 是一种环戊基衍生物，具有用于帕金森病研究的潜力。

CaV1.3 antagonist-1 is a potent and highly selective Ca V 1.3 L-type calcium channel (LTCC) antagonist with an IC 50 of 1.7 μM. CaV1.3 antagonist-1 inhibits Ca V 1.3 LTCC >600-fold more potently than Ca V 1.2 LTCC. CaV1.3 antagonist-1, a cyclopentyl derivative, has the potential for Parkinson's disease research [1].

CaV1.3 antagonist-1 (Compound 8; 5 μM) exhibits 31.2% and 4.4% inhibition for Ca V 1.3 and Ca V 1.2 channel current in HEK293 cells, respectively. This correlates with the results of the FLIPR assay [1].

1391385-57-1

C17H19ClN2O3

334.8

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years