PPM-18 (NSC 73233) 是一种有效的抗炎剂,可抑制一氧化氮合酶的表达。PPM-18 是有效的 iNOS 表达抑制剂,可阻断 NF-Κb 与启动子的结合。PPM-18 是维生素 K 的类似物,通过 ROS 和 AMPK 信号通路诱导膀胱癌细胞自噬和凋亡。
产品描述
PPM-18 (NSC 73233) is a potent anti-inflammatory agent which inhibits nitric oxide synthase expression. PPM-18 is a potent inhibitor of iNOS expression by blocking the binding of NF-κB to promoter [1]. PPM-18 is an analog of Vitamin K remarkably suppressed the proliferation and induced apoptosis in bladder cancer cells [2].
Cas No.
65240-86-0
分子式
C17H11NO3
分子量
277.27
别名
PPM-18
储存和溶解度
(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years