您好,欢迎来到化工原料网! [登录] [免费注册]
化工原料网
位置:首页 > 产品库 > SBP-0636457
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
SBP-0636457
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
SBP-0636457图片
CAS NO:1422180-49-1
包装与价格:
包装价格(元)
5 mg电议
100 mg电议
500 mg电议

产品名称
SB1-0636457
SBI-0636457
产品介绍

产品描述

SBP-0636457 (SB1-0636457) is a SMAC mimetic, and as an IAP antagonist. SBP-0636457 binds to the BIR-domains of the IAP proteins , with a K i of 0.27 μM. SBP-0636457 can be used for the research of solid tumors and hematologic cancers.

体外活性

SBP-0636457 (1-20 μM) demonstrates no cytotoxicity in BT474, BT549, MCF7, and MDA-MB-231 breast cancer cell lines up to a concentration of 20μM[1]. SBP-0636457 (10-1000 nM; 20 h) is ef?cacious as TRAIL-sensitizing agents in MDA-MB-231 cells, with an EC 50 of 9 nM[1].

Cas No.

1422180-49-1

分子式

C25H36N4O4

分子量

456.58

别名

SBP-0636457;SB1-0636457;SBI-0636457;SBP-0636457

储存和溶解度

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years