α7 nAChR-JAK2-STAT3 agonist 1 是一种有效的α7 nAChR-JAK2-STAT3通路抑制剂，对一氧化氮 (NO)的IC50为 0.32 μM。α7 nAChR-JAK2-STAT3 agonist 1 在小鼠巨噬细胞 RAW264.7 中有效抑制 iNOS、IL-1β 和 IL-6 的表达。α7 nAChR-JAK2-STAT3 agonist 1 能抑制 LPS 诱导的 NO 释放、NF-Κb 激活和细胞因子产生。α7 nAChR-JAK2-STAT3 agonist 1 可用于败血症的研究。

α7 nAchR-JAK2-STAT3 agonist 1 is a potent α7 nAchR-JAK2-STAT3 agonist, with an IC 50 value of 0.32 μM for nitric oxide (NO). α7 nAchR-JAK2-STAT3 agonist 1 effectively suppresses the expression of iNOS, IL-1β, and IL-6 in murine RAW264.7 macrophages. α7 nAchR-JAK2-STAT3 agonist 1 can inhibit LPS-induced NO release, NF-κB activation and cytokine production. α7 nAchR-JAK2-STAT3 can be used for researching sepsis [1].

2108714-20-9

C25H30O6

426.5

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years