Anticancer agent 50 (compound 6) 是一种有效的 ABCB1 外排泵调节剂。Anticancer agent 50 显示细胞毒作用和抗增殖作用。Anticancer agent 50 降低细胞周期蛋白 D1 的表达并诱导 p53 表达。Anticancer agent 50 具有研究T淋巴瘤的潜力。

Anticancer agent 50 (compound 6) is a potent ABCB1 efflux pump modulator. Anticancer agent 50 shows cytotoxic effects and antiproliferative effects. Anticancer agent 50 decreases the expression of cyclin D1 and induces p53 expression. Anticancer agent 50 has the potential for the research of T-lymphoma [1].

Anticancer agent 50 (compound 6) (0-100 μM) shows cytotoxic effects with IC 50 s of 0.67, 0.90 μM for sensitive parental (PAR) and resistant (MDR) mouse T-lymphoma cells, respectively [1]. Anticancer agent 50 (0-100 μM) shows antiproliferative effects with IC 50 s of 3.84, 1.34 μM for sensitive parental (PAR) and resistant (MDR) mouse T-lymphoma cells, respectively [1]. Anticancer agent 50 (0.1, 0.5, 2 μM; 24 h) inhibits cell cycle progression through the reduction of the expression of cyclin D1 and inhibits cell proliferation by inducing p53 expression [1]. Anticancer agent 50 (0.1, 0.5, 2, 10 μM; 72 h) inhibits cell growth by 12% in SH-SY5Y cells [1]. RT-PCR [1] Cell Line: JURKAT cells Concentration: 0.1, 0.5, 2 μM Incubation Time: 24 h Result: Significantly reduced cyclin D1 expression and increased the level of p53.

2487457-15-6

C30H32N2O4Se

563.55

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years