(±)5-HEPE is produced by non-enzymatic oxidation of EPA. It contains equal amounts of 5(S)-HEPE and 5(R)-HEPE. The biological activity of (±)5-HEPE is likely mediated by one of the individual isomers, most commonly the 5(S) isomer in mammalian systems. EPA can be metabolized to 5-HEPE in human and bovine neutrophils, and human eosinophils, which is further metabolized to 5-oxoEPE and LTB5. The 5-series metabolites of EPA, namely 5-HEPE, 5-oxoEPE, and LTB5, have significantly decreased biological effects compared to the arachidonic acid-derived metabolites.

83952-40-3

C20H30O3

318.45

(±)5-HEPE

DMSO:Miscible
PBS (pH 7.2):0.8 mg/mL
Ethanol:Miscible
DMF:Miscible
0.1 M Na2CO3:2 mg/mL
Powder: -20°C for 3 years
In solvent: -80°C for 2 years