SIRT1-IN-3 (compound 3j) 是一种有效且选择性的SIRT1抑制剂，其IC50为 4.2 μM。

SIRT1-IN-3 (compound 3j) is a potent and selective SIRT1 inhibitor, with an IC 50 of 4.2 μM [1].

SIRT1-IN-3 (compound 3j) (0-100 μM, 48 h) inhibits the proliferation of human cancer cell lines including K562, HCT-116, H460, HepG2, A549, and MCF-7, and shows low cytotoxic on 293T and HUVEC [1]. Cell Cytotoxicity Assay Cell Line: Human cancer cell lines (K562, HCT-116, H460, HepG2, A549, HT-29, MCF-7) and normal cell lines (293T, HUVEC) [1] Concentration: 0, 0.01, 0.1, 1, 10, 100 μM Incubation Time: 48 h Result: Inhibited the proliferation of Human cancer cell lines including K562, HCT-116, H460, HepG2, A549, and MCF-7, with IC 50 values of 47, 41, 66, 93, 52, and 64 μM, respectively. And showed low cytotoxic on 293T and HUVEC, with an IC 50 values of 49 and 45 μM, respectively.

2470969-91-4

C13H15BrN2O

295.18

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years