Competitive PTP1B inhibitor (IC50 = 0.781 μM). Binds catalytic P-loop of enzyme. Improves insulin sensitivity in obese mice in the glucose tolerance test and the homeostasis model assessment of insulin resistance index (HOMA-IR). Enhances insulin-induced glucose uptake in adipocytes and myotubes in vitro. Exhibits some selectivity for PTP1B over other protein tyrosine phosphatases, except TCPTP.

1256341-22-6

C28H39NO4

453.61

CX08005

DMSO:Soluble
Powder: -20°C for 3 years
In solvent: -80°C for 2 years