JMS-053 等效抑制 PTP4A3 及其近亲成员 PTP4A1 和 PTP4A2，IC50 分别为 34.7 nM、29.1 nM 和 48.0 nM。 JMS-053 抑制致癌双特异性磷酸酶 CDC25B，IC50 值为 92.6 nM。 JMS-053 是双特异性磷酸酶 DUSP3 的抑制剂，IC50 为 207.6 nM。 JMS-053 在体外抑制癌细胞迁移和球体生长，减弱体内卵巢肿瘤生长，并减轻血管内皮生长因子或脂多糖对微血管内皮屏障功能的破坏。

JMS-053 is equipotent to inhibit PTP4A3 and its close family members PTP4A1 and PTP4A2 with IC50s of 34.7 nM, 29.1 nM, and 48.0 nM. JMS-053 inhibits the oncogenic dual specificity phosphatase CDC25B with an IC50 value of 92.6 nM. JMS-053 is an inhibitor of the dual specificity phosphatase DUSP3 with IC50 of 207.6 nM. JMS-053 inhibited cancer cell migration and spheroid growth in vitro, attenuated in vivo ovarian tumor growth, and mitigated the disruption of the microvascular endothelial barrier function by vascular endothelial growth factor or lipopolysaccharide [1].

1954650-11-3

C13H8N2O2S

256.28

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years