Platyconic Acid A is an active component of changkil saponins from platycodon grandiflorum and can be used for the research of reducing airway inflammation.

Platyconic Acid A (0.5~2 μM; 30 minutes; A549 cells) inhibits PMA-induced NF-κB p65 phosphorylation, IκBα phosphorylation and degradation and Akt phosphorylation in a concentration-dependent manner[1]. Platyconic Acid A (0.5~2 μM; 24 hours; A549 cells) decreases PMA-increased MUC5AC mRNA expression in a concentration-dependent manner[1]. Western Blot Analysis[1]Cell Line: A549 cells Concentration: 0.5~2 μM Incubation Time: 30 minutes Result: Inhibited PMA-induced NF-κB p65 phosphorylation, IκBα phosphorylation and degradation and Akt phosphorylation in a concentration-dependent manner. RT-PCR[1]Cell Line: A549 cells Concentration: 0.5~2 μM Incubation Time: 24 hours Result: Decreased PMA-increased MUC5AC mRNA expression in a concentration-dependent manner.

68051-23-0

C57H90O29

1239.318

Platyconic acid A

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years