Lp-PLA2-IN-3 is a potent and orally bioavailable lipoprotein-associated phospholipase A2 (Lp-PLA2) inhibitor, with an IC50 of 14 nM for recombinant human Lp-PLA2 .

Lp-PLA2-IN-3 (1 mg/kg; i.v.) treatment shows the CL, Vss, and t1/2 were 3.1mL/min/kg, 0.3 L/kg, 4 hours, respectively[1].Lp-PLA2-IN-3 (3 mg/kg;?p.o.) treatment shows the Cmax, AUC0-24h, t1/2 and F were 0.27 μg/mL, 3.4 μg h/mL, 7.7 hours and 35.5%, respectively[1].

2196245-16-4

C20H13ClF3N3O3S

467.85

Lp-PLA2-IN-3

DMSO:250 mg/mL (534.36 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years