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MT-DADMe-ImmA
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
MT-DADMe-ImmA图片
CAS NO:653592-04-2
包装与价格:
包装价格(元)
1 mg电议
5 mg电议
10 mg电议
25 mg电议
50 mg电议
100 mg电议
200 mg电议
500 mg电议
1 mL*10 mM(in DMSO)电议

产品名称
MTDIA
Methylthio-DADMe-Immucillin A
产品介绍
MT-DADMe-ImmA 是一种人5'-甲硫基腺苷磷酸化酶的抑制剂 (MTAP)(Ki:90 pM)。

产品描述

MT-DADMe-ImmA is an inhibitor of human 5'-methylthioadenosine phosphorylase (MTAP, Ki: 90 pM).

体外活性

Treatment of cultured cells with MTA and MT-DADMe-ImmA inhibit MTAP, increase cellular MTA concentrations, decrease polyamines, and induce apoptosis in FaDu and Cal27, two head and neck squamous cell carcinoma cell lines. MT-DADMe-ImmA alone does not induce apoptosis in any cell line [2].

体内活性

MTAP activity slowly returns, giving a biological half-life for the action of oral MT-DADMe-ImmA of 6.3 days. The time-dependent growth of FaDu tumors in immunodeficient mice is suppressed by oral or intraperitoneal treatment with MT-DADMe-ImmA [2].

细胞实验

Cell viability is evaluated using the Alamar Blue assay. Cells are seeded onto 96-well plates at a density of 10^4 cells/well and incubated with increasing concentrations of MT-DADMe-ImmA (100 pM to 100 μM) for 4 days at fixed MTA concentrations (0, 5, 10, and 20 μM) [2].

动物实验

Tumors were established in mice for 5 days prior to oral or intraperitoneal treatments with MT-DADMe-ImmA. Mice are treated with an oral dose of 21 mg/kg or an intraperitoneal dose of 5 mg/kg/day MT-DADMe-ImmA [2].

Cas No.

653592-04-2

分子式

C13H19N5OS

分子量

293.39

别名

MTDIA;Methylthio-DADMe-Immucillin A;MT-DADMe-ImmA

储存和溶解度

DMSO:50 mg/mL (170.42 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years