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CMP-5 hydrochloride
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
CMP-5 hydrochloride图片
CAS NO:1030021-40-9
包装:5 mg
市场价:7000元

产品介绍

体外活性

CMP-5 (0-100 μM; 24-72 hours) is selectively toxic to lymphoma cells but shows limited toxicity to normal resting B lymphocytes even after prolonged incubation. CMP-5 (0-40 μM; 24 hours) preferentially suppresses the proliferation of human Th1 cells over Th2 cells (43 versus 9% inhibition, respectively). The sensitivity of Th1 cells over Th2 cells to PRMT5 inhibition is different, the IC50 values are 26.9 μM and 31.6 μM in human Th1 cells and Th2 cells, respectively. CMP-5 (40 μM; 24 hours) decreases p-BTK and pY(416)SRC expression in 60A cells when it compares to the DMSO-treated group. CMP-5 (25 μM; 24 hours) alone inhibits mouse Th1 cell proliferation by 91%, when added different doses IL-2, IL-2 enhances proliferation and reaches a peak at 5 ng/ml [1].

Cas No.

1030021-40-9

分子式

C21H22ClN3

分子量

351.87

别名

CMP-5 hydrochloride

储存和溶解度

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years