KH-259 (compound 1) 是一种有效的、选择性和可透过中枢神经系统的HDAC6抑制剂，其IC50为 0.26 μM。KH-259 通过抑制小鼠脑内 HDAC6 产生抗抑郁作用。KH-259 可用于神经退行性疾病研究。

KH-259 (compound 1) is a potent, selective and CNS-penetrant HDAC6 inhibitor, with an IC 50 of 0.26 μM. KH-259 has antidepressant effects in mice through the inhibition of HDAC6 in the brain. KH-259 can be used for neurodegenerative diseases research [1].

KH-259 (compound 1) exhibits acceptable metabolic stability in both mouse and human liver microsomes [1].

KH-259 (compound 1) (10 mg/kg, IP, once) in mice significantly increases acetylated α-tubulin levels without increasing acetylated histone H3K9 levels in the brain, indicating that KH-259 has antidepressant effects in mice through the inhibition of HDAC6 in the brain [1].

C20H25N3O2

339.43

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years