Compound 48/80 trihydrochloride is a mixture of condensation products of N-methyl-p-methoxyphenethylamine with formaldehyde. It inhibits phosphatidylinositol-specific phospholipase C activity from human platelets. It is also a histamine releaser and a mast cell degranulator.

Compound 48/80 trihydrochloride inhibits both cytosolic and particulate phosphatidylinositol-specific phospholipase C activities with similar efficiency (IC50s: 2.1 μg/ml (supernatant) and 5.0 μg /ml (particulate fraction)). The aggregation of human platelets induced by ADP and PAF-acether is inhibited by Compound 48/80 [1].

Compound 48/80 trihydrochloride causes oxidative stress in the rat adrenal gland through mast cell degranulation. Compound 48/80 trihydrochloride (0.75 mg/kg; i.p.; Killed after 0.5, 3, or 6 h) increases serum serotonin, histamine, and corticosterone levels at 0.5 h, but their increases were reduced thereafter [3].

848035-21-2

C32H48Cl3N3O3

629.1

C48/80 trihydrochloride;Compound 48/80 trihydrochloride

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years