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Sedanolide
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Sedanolide图片
CAS NO:6415-59-4
包装与价格:
包装价格(元)
10 mg电议
1 mL*10 mM(in DMSO)电议

产品介绍
Sedanolide 是从伞形科的种子油中分离出的一种天然苯酞,具有抗炎和抗氧化活性。

产品描述

Sedanolide is a natural phthalide first isolated from seed oil of the Umbelliferae family, including celery.

体外活性

Sedanolide suppressed J5 cell viability by inducing autophagy. Phosphoinositide 3-kinase (PI3K)-I, mammalian target of rapamycin (mTOR) and Akt protein levels decreased, whereas PI3K-III, LC3-II and Beclin-1 protein levels increased following Sedanolide treatment in J5 cells. In addition, Sedanolide treatment upregulated nuclear p53 and damage-regulated autophagy modulator (DRAM) and downregulated cytosolic p53 and Tp53-induced glycolysis and apoptosis regulator (TIGAR) expression in J5 cells. Furthermore, the cytosolic phosphorylation of inhibitor of kappa B (IκB) and nuclear p65 and the DNA-binding activity of NF-κB increased after Sedanolide treatment. These results suggest that Sedanolide induces J5 cell autophagy by regulating PI3K, p53 and NF-κB autophagy-associated signaling pathways in J5 cells.

Cas No.

6415-59-4

分子式

C12H18O2

分子量

194.274

别名

Sedanolide

储存和溶解度

DMSO:10 mM
Powder: -20°C for 3 years
In solvent: -80°C for 2 years