UNC-2170 是53BP1 (IC50=29 μM;Kd=22 μM) 选择性的、功能活性的片段状配体，对 53BP1 的选择性比其他九种甲基赖氨酸读取器蛋白质高出至少17倍。53BP1 是 Kme 结合蛋白，在 DNA 损伤修复途径中起核心作用，并被招募到双链断裂位点。

UNC2170 Maleate is the methyl-lysine binding protein, 53BP1 ligand.

UNC-2170 (500 μM) results in a significant increase in soluble 53BP1 as compared to lysates treated with UNC2892, the negative control compound. UNC-2170 (30-100 μM; naive splenocytes cultured with LPS and IL-4 for 3.5 days) clearly phenocopies the reduction in CSR seen in 53BP1 mutant B cells[1].

1648707-58-7

C14H21BrN2O

313.23

UNC-2170 Maleate;UNC 2170 Maleate;UNC2170 Maleate;UNC-2170

DMSO:60 mg/ml (191.55 mM),Need ultrasonic
Methanol:125 mg/mL (399.07 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years